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Indian Institute of Technology Bhubaneswar
Indian Institute of Technology Bhubaneswar

Dr. Anasuya Roychowdhury Associate Professor
School of Basic Sciences

Research Interests

  • Oncogenic mechanisms of gastrointestinal (Stomach/gastric, pancreatic, colorectal) cancers 
  • Cancer and gut microbiome
  • Cancer therapeutics
  • Cancer biomarkers

Contact Details

  • SBS-315
  • 674-713-5106
  • aroychowdhury@iitbbs.ac.in

Other Profile Link(s)

Education

 Degree Discipline Year School
  Ph.D. Biochemistry and Molecular Biology 2009 University Of Texas Medical Branch at Galveston, Texas, USA
 

Biosketch

 

Teaching

Undergraduate (B.Tech.) Courses: 
  • An Introduction to Bioscience & Technology [BS2L001]:  B.Tech. 2nd year course (2-0-0)
  • Genetic Engineering [CY3L001]: B.Tech. 2nd year course (3-0-0)
  • Chemistry Laboratory [CY5S001]: B.Tech. First year course (0-0-3)
Post-graduate (M.Sc./Ph.D.) Courses:  
  • Chemistry of Pharmaceutics [CY7L030]: Joint M. Sc. Chemistry/Ph.D. course (3-0-0)
  • Biochemistry [CY7L001]: Joint M. Sc. Chemistry/Ph.D. course (3-0-0)
  • Thermodynamics and Chemical Equilibrium [CY5L005]: M.Sc. Chemistry (3-1-0)
  • Literature survey & seminar I [CY5S001]: M.Sc. Chemistry (0-0-3)
  • Advanced Instrumentation Laboratory [CY5P004]: M.Sc. Chemistry (0-0-6)
  • Physical Chemistry Laboratory [CY5L003]: M.Sc. Chemistry (0-0-6) 
 

Projects

  • ASPIRE Grant (2024-27). Sponsoring Agency: CSIR, India. Role: PI (approved)
  • Extramural Ad-Hoc Grant (2021-24). Sponsoring Agency: ICMR, India. Role: PI (completed).
  • R&D grant (2020-23). Sponsoring Agency: DBT, India. Role: PI (completed).
  • Vanderbilt International Research Grant (2015-17). Sponsoring Agency: Vanderbilt International Research Grants Program, Vanderbilt University, USA. Role: PI (completed).
  • Seed Money Project (2014-16). Sponsoring Agency: IIT Bhubaneswar; Role: PI (completed).
  • Indo-US Joint Centre (2014-2017). Sponsoring Agency: The Indo-US Science and Technology Forum (IUSSTF); Role: co-PI (completed).
 
 

Recent Publications (International Journals)

11. Complete Genome Sequence, Metabolic Profiling and Functional Studies reveal Ligilactobacillus salivarius LS-ARS2 is a Promising Biofilm-forming Probiotic with Significant Antioxidant, Antibacterial, and Antibiofilm Potential. S. Patra, B. Pradhan and A. Roychowdhury Front. Microbiol. 2025; 16:1535388. https://doi.org/10.3389/fmicb.2025.1535388. [Q1; IF=4.0]
2A study of a survival data using kernel estimates of hazard rate and aging intensity functions, M. Szymkowiak, A. Roychowdhury, S.K. Misra, R Giri, S Bhattacharjee, Statistics in Transition New Series 2023; Volume 24, Pages 109-127.https://doi.org/10.59170/stattrans-2023-066
3ATAD2 Suppression Enhances the Combinatorial Effect of Gemcitabine and Radiation in Pancreatic Cancer Cells, M. Dutta, D. Mohapatra, A.P. Mohapatra, S. Senapati, A. Roychowdhury. Biochem Biophys Res Commun. 2022; 635:179-186. doi: 10.1016/j.bbrc.2022.10.021 [Q2; I.F=3.575].
4MicroRNA-217 Modulates Pancreatic Cancer Progression via Targeting ATAD2. M. Dutta, B. Das, D. Mohapatra, P Behera, S Senapati, A. Roychowdhury, Life Sci. 2022; 301:120592. doi: 10.1016/j.lfs.2022.120592. [Q1; I.F=5.037].
5Effects of Probiotics at the Interface of Metabolism and Immunity to Prevent Colorectal Cancer-Related Gut-inflammation: A Systematic Network and Meta-analysis with Molecular Docking Studies, S. Patra, N. Sahu, S. Saxena, B. Pradhan, S. K. Nayak, A. Roychowdhury, Front Microbiol. 2022;13:878297. doi: 10.3389/fmicb.2022.878297 [Q1; I.F=5.64].
6Emerging oncogene ATAD2: Signaling cascades and therapeutic initiatives. A Nayak, M Dutta, A Roychowdhury, Life Sci. 2021;276:119322. doi: 10.1016/j.lfs.2021.119322 [Q1; I.F=5.037].
7Systematic network and meta-analysis on the antiviral mechanisms of probiotics: a preventive and treatment strategy to mitigate SARS-CoV-2 infection. S Patra, S Saxena, N Sahu, B Pradhan, A Roychowdhury, Probiotics and antimicrobial proteins, 2021;13(4):1138-1156. doi: 10.1007/s12602-021-09748-w [Q2; I.F=4.609].
8Oncogenic potential of ATAD2 in stomach cancer and insights into the protein-protein interactions at its AAA+ ATPase domain and bromodomain. A Nayak, S Kumar, SP Singh, A Bhattacharyya, A Dixit, A Roychowdhury. J Biomol Struct Dyn. 2021:1-17. doi: 10.1080/07391102.2021.1871959 [Q2; I.F=3.392].
9HIF1α-dependent upregulation of ATAD2 promotes proliferation and migration of stomach cancer cells in response to hypoxia. A Nayak, AD Roy, N Rout, SP Singh, A Bhattacharyya, A Roychowdhury, Biochem Biophys Res Commun. 2020;523(4):916-923. doi: 10.1016/j.bbrc.2019.12.130 [Q2; I.F=3.575].
10Mechanisms of interactions of the nucleotide cofactor with the RepA protein of plasmid RSF1010. Binding dynamics studied using the fluorescence stopped-flow method IE Andreeva, A Roychowdhury, MR Szymanski, MJ Jezewska, W. Bujalowski. Biochemistry. 2009; 48(44):10620-36. doi: 10.1021/bi900940q [Q1; I.F=3.162].
11Interactions of the Escherichia coli DnaB−DnaC Protein Complex with Nucleotide Cofactors. 1. Allosteric Conformational Transitions of the Complex. A Roychowdhury, MR Szymanski, MJ Jezewska, W Bujalowski, Biochemistry. 2009;48(29):6712-29. doi: 10.1021/bi900050x [Q1; I.F=3.162].
12Mechanism of NTP Hydrolysis by the Escherichia coli Primary Replicative Helicase DnaB Protein. 2. Nucleotide and Nucleic Acid Specificities. A Roychowdhury, MR Szymanski, MJ Jezewska, W Bujalowski. Biochemistry. 2009; 48(29):6730-46. doi: 10.1021/bi9000529 [Q1; I.F=3.162].
13Escherichia coli DnaB Helicase−DnaC Protein Complex: Allosteric Effects of the Nucleotides on the Nucleic Acid Binding and the Kinetic Mechanism of NTP hydrolysis. 3. A Roychowdhury, MR Szymanski, MJ Jezewska, W Bujalowski. Biochemistry. 2009; 48(29):6747-63. doi: 10.1021/bi9000535 [Q1; I.F=3.162].
14Accumulation of p-hydroxybenzoic acid in hairy roots of Daucus carota. D Sircar, A Roychowdhury, A Mitra J Plant Physiol. 2007; 164(10):1358-66. doi: 10.1016/j.jplph.2006.08.002 [Q1;I.F=3.549].
15Kinetic mechanisms of the nucleotide cofactor binding to the strong and weak nucleotide-binding site of the Escherichia coli PriA helicase. 2 AL Lucius, MJ Jezewska, A Roychowdhury, W Bujalowski. Biochemistry. 2006; 45(23):7217-36. doi: 10.1021/bi051827e [Q1; I.F=3.162].

Conferences (International)

1Patra S. and Roychowdhury A., Lactobacillus plantarum shows Probiotic Potential and Antioxidant properties for the Prevention of Colorectal Cancer. J. Biol. Chem. (2023) 299(3S) S53-54, https://doi.org/10.1016/j.jbc.2023.103169.
2Roychowdhury A, Nayak A, Kumar S, Dixit A, BhattacharyyaA. Hypoxia-responsive and HIF1α-regulated AAA+ ATPase ATAD2 shows high oncogenic potential in stomach cancer [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2022; 2022 Apr 8-13. Philadelphia (PA): AACR; Cancer Res 2022;82(12_Suppl):Abstract nr 5680. https://doi.org/10.1158/1538-7445.AM2022-5680
3Nayak A, Kumar S, Bhattacharyya A, Dixit A, Roychowdhury A (2019). Cross-Cancer Study with a Special Emphasis on Stomach Cancer Reveals ATAD2 as Diagnostic and Prognostic Biomarker. Mol Biol Cell 30(26), pp. P-1150. https://doi.org/10.1091/mbc.E19-11-0617.
4Roychowdhury A, Nayak A, Bhattacharyya A. (2019). AAA+ ATPase ATAD2 signalling networks in gastric cancer. Biochem Mol Biol J Vol.5; doi: 10.21767/2471-8084-C3-029.
5Roychowdhury A, Robert J, Lee BH, Finley D. Characterization of the Non-catalytic Inhibitory Effect of Ubp6 on Proteasome Function. FASEB J. 27:553.23, 2013. https://doi.org/10.1096/fasebj.27.1_supplement.553.23
6Roychowdhury A, Jezewska MJ, Bujalowski W. Nucleotide Control of Replication Initiation: NTPase Mechanisms of E.coli DnaB-DnaC Complex. Biophysical J., vol. 96, issue 3, pp. 209a-209a, 2009.
7Roychowdhury A, Jezewska MJ, Bujalowski W. (2009). E.coli DnaB-DnaC Complex with Nucleotide Cofactors: An Allosteric Control of Recognition Process in DNA Replication. Special Issue: The 23rd Symposium of The Protein Society 2009: Abstract 235, Protein Science. vol. 18, issue S1, pp 137.
8Roychowdhury A, Jezewska MJ, Bujalowski W. (2008) Functional Studies of E.coli DnaB-DnaC Complex Indicates Its Role As a Part of Primosome. 2008 Biophysical Society Meeting Abstracts. Biophysical J., Supplement, vol. 94, issue 2, Abstract, pp. 675.
9Lucius, AL, Jezewska MJ, Roychowdhury A, Bujalowski W. (2006) Kinetic Mechanisms of the nucleotide Cofactor binding to the Strong and Weak Nucleotide-Binding Site of the Escherichia coli PriA Helicase. 2006 Biophysical Society Meeting Abstracts. Biophysical J., Supplement, vol. 90, Abstract, 981-Pos.
 

Academic Honors & Awards

  • Vanderbilt International Research Grant Award by Vanderbilt International Research Grants Program, Vanderbilt University, USA (2015).
  • Postdoctoral Research Fellowship, Harvard Medical School, Boston, MA (2010).
  • Irma Mendoza Scholarship Award, UTMB, Galveston, Texas (2009).
  • Biochemistry and Molecular Biology (BMB) Travel Award, UTMB, Galveston, Texas (2009).
  • The Protein Society Finn Wold Travel Award (2009).
  • The Robert A. Welch Award for Excellence in Graduate Research in Chemistry, UTMB, Galveston,Texas (2007).
  • Graduate Assistant Fellowship, UTMB, Galveston, Texas (2004).
  • Qualified GATE in Life Sciences (2002).
 

Research Scholar

  • Ph. D. students: 2 completed; 2 continuing
  • M.Sc. students : 11 completed; 1 continuing
 
 

Professional Experience

1.  Assistant Professor, Indian Institute of Technology Bhubaneswar, India (2013-2022) 2.  Postdoctoral Research Fellow, Harvard Medical School, USA (2010-2013)

Membership in scientific societies

  • Life Member, Indian Association of Cancer Research (IACR)
  • Life member, Indian Society of Translational Research (ISTR)
  • Life member, Society of Biological Chemists India (SBCI)

Book chapter

Dutta M, Patra S, Saxena S, Roychowdhury, A*. Antimicrobials: Targets, Functions and Resistance. An invited book chapter of “Biomolecular Engineering Solutions for Renewable Specialty Chemicals: Microorganisms, Products, and Processes” (John Wiley & Sons, Inc.); pages 77-109; October 25, 2021.

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PIN - 752050, ODISHA
Phone: +91 674 7134550, +91 674 7134551
Email: registrar@iitbbs.ac.in

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Address :Indian Institute of Technology Bhubaneswar
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