Cell: The Unit of Life: The concept of cell in the perspective of a whole living body; Concept of cell, tissue system, organ and whole organism. Brief overview of plant and animal cell.
Genes are DNA & Bioinformatics: DNA is the genetic material; Structural aspects–components of DNA and RNA, Nucleosides & Nucleotides (introduction, structure & bonding), Double helical structure of DNA (Watson and Crick model). Mutations change the sequence of DNA, a gene codes for a single polypeptide, recombination occurs by physical exchange DNA, genetic code is triplet. NCBI, protein primary sequence analysis, DNA sequence analysis, sequence alignment, BLAST, multiple sequence alignment; CLUSTALW.
Expression of genetic information: Central dogma: The Relationship between genes and protein, Visualization of protein structure using PyMol, The Central dogma; The basic processes of DNA replication, RNA Transcription and Protein translation; Protein function: Enzymes as a case study.
Mutation and Disease: Occurrence, kinds of Mutation, spontaneous & induced Mutation, Mutagens, detection of Mutation, Lethal Mutations, Biochemical Mutations, Phenotypic effects of Mutation, Molecular basis of Mutation, Significance & Practical applications of Mutation.
Immune system:An overview of immune system.
Genetic Engineering: Recombinant DNA technology and basic genetic engineering techniques; some case studies: Cholera Toxin, Bt toxins, GM food, transgenic plants.
Text/Reference Books:
- Nelson D. L. and Cox M. M. Lehninger Principles of Biochemistry, W. H. Freeman & Company.
- Lodish H.; Berk A. and Kaiser C. A. Molecular Cell Biology & eBook, W. H. Freeman & Company.
- Voet and Voet. Biochemistry, Wiley.
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